Hypolipidemic Activity of Sesquiterpene Lactones and their Derivatives

BACKGROUND: Despite the available range of lipid-lowering drugs, mainly synthetic origin, problem atherosclerosis therapy and its manifestations remain unresolved. Bioinformatics methods, in particular molecular docking, are considered as a promising direction terms developing effective original drugs. Today, source natural agents, it is advisable to consider terpenoids, namely sesquiterpene lactones, which distinguished by wide pharmacological activity. This article presents results virtual biological screening activity γ-lactones their chemically modified derivatives. AIM: The aim evaluate properties samples derivatives methods. METHODS: Molecular modeling binding energy “ligand-target” complex (docking). docking was performed using Glide program from developer Schrodinger Small-Molecule Drug Discovery package Extra Precision algorithm (https://www.schrodinger.com/glide). effect lactones on expression genes for key enzymes lipid metabolism liver studied an vivo model hyperlipidemia caused atherogenic diet. CONCLUSION: Virtual revealed number compounds (matricin, matricarin, grossmisin oxime, austricin 5β (H)-austricin) receptor interactions enzyme system cholesterol 7α-hydroxylase (CYP7A1). New mechanisms were proposed, established study gene diet rats under conditions.